Creatine+
Advanced creatine for longevity, strength, and cognition.
Creatine+ by Elysium Health is a 3-in-1 creatine system built for longevity, strength, and cognition—formulated with the advisement of Michael Fredericson, M.D., Co-Director of the Stanford Center on Longevity and Professor of PM&R Sports Medicine at Stanford University.
Creatine monohydrate: Highest purity, solubility, and most bioavailable creatine monohydrate—to increase lean muscle and strength and support cognitive function.¹
HMB (β-hydroxy β-methylbutyrate): Works additively with creatine to enhance muscle recovery and reduce damage due to exercise, helping you keep more of the muscle you build.
Pomegranate polyphenols (standardized to urolithin A precursors): Promotes mitochondrial renewal and energy.²
Creatine+ is an advanced creatine system for longevity, strength, and cognition that combines:
- 5 g creatine monohydrate
Gold standard, ultra-high quality, purity and bioavailable creatine monohydrate, micronized for high solubility.
- 1.5 g β-hydroxy β-methylbutyrate (HMB)
Works synergistically with creatine to enhance muscle recovery and reduce damage due to exercise.*
- 300 mg pomegranate extract
A clinically studied pomegranate extract standardized to high levels of UA precursors, to support mitochondrial health and energy production throughout the body.
Gluten-free, dairy-free, soy-free, sugar-free, non-GMO, and contains no artificial flavors or colors.
See nutrition label for more information.
The quality and purity information of every lot is available here.
Creatine, finally
built for longevity
Beyond the gym. Beyond today. Creatine+ was formulated for the benefits that matter most for longevity.
Stay strong for life
Muscle loss accelerates with age—and the stakes are higher than performance. Creatine and HMB work together to support muscle preservation and physical function.1 Vitamin D3 contributes to normal muscle function and bone health, supporting the foundation that keeps you strong for decades.
Power your cells
Pomegranate polyphenols provide precursors to urolithin A—a compound shown to promote mitochondrial renewal at the cellular level.2 While creatine replenishes energy during activity, urolithin A supports the sustained energy production that powers everything else.
Support your brain
The brain consumes approximately 20% of the body's total energy. Creatine is found in small but vital amounts in the brain, and emerging evidence suggests higher doses of creatine (~2-4x Creatine+) may support cognitive function—particularly under metabolic stress, such as sleep deprivation or sustained mental effort.3
Build strength. Keep it.
Creatine rapidly replenishes cellular energy to enhance exercise capacity, increasing lean muscle and strength when combined with resistance training. HMB reduces muscle damage after exercise and accelerates recovery—helping you keep what you build.
680+
clinical trials behind creatineThe most studied form of creatine. Now in a novel longevity formula.
Creatine+ pairs the most-studied form of creatine with HMB and pomegranate polyphenols—for strength you build, muscle you keep, and cellular energy that lasts.
Not all creatine is created equal
Creatine+ combines three clinically studied ingredients—creatine monohydrate, HMB, and pomegranate polyphenols standardized to urolithin A precursors—each targeting distinct pathways of longevity, strength, and recovery. See how it compares.
“What’s unique about Creatine+ is that it optimizes for two critical components of athletic performance—both output and recovery.”
Michael Fredericson, M.D., Co-Director of the Stanford Center on Longevity and Professor of PM&R Sports Medicine at Stanford University
Benefits that build over time
Creatine+ is formulated for strength, cognition, and longevity—with benefits that begin at the cellular level and build with consistent daily use.4
- 24 hours
Your cells get to work
Gut microbes begin converting pomegranate polyphenols into urolithin A, entering systemic circulation to promote mitochondrial renewal throughout the body.2
- 30 days
Full muscle saturation
Total creatine in muscle rises to saturation—a 20% increase. Emerging evidence suggests higher doses of creatine (2-4x Creatine+) may also support cognitive function during periods of metabolic stress, such as sleep deprivation.3
- 12 weeks
Strength you can measure
Improved training adaptation and increased exercise capacity drive significant gains in strength and lean muscle when combined with resistance training. HMB reduces muscle damage after exercise and accelerates recovery—helping you keep what you build.
- 1 year
Muscle that lasts
A 12-month trial of HMB and vitamin D3 demonstrated increased muscle strength and physical function in older adults—even without exercise.5
1. When combined with resistance training.
2. As UA production is dependent on colonic bacteria, the extent of UA conversion can vary depending on the individual’s metabotype; the 24-hour timepoint is approximate.
3. Brain creatine increases have been demonstrated at 20 g/day doses. The 5 g/day dose in Creatine+ is designed to support muscle creatine saturation; its effect on brain creatine at this dose has not been established.
4. Individual results may vary. This timeline may be different from the typical purchaser’s experience, and is not intended to represent or guarantee that anyone will receive the same or similar results.
5. Demonstrated in older adults with insufficient baseline vitamin D levels. Creatine+ contains 1.5 g HMB per serving and 12.5 mcg (500 IU) vitamin D3, lower than the amount of HMB and vitamin D3 administered in the study.
Frequently Asked Questions
What is creatine and what does it do?
Creatine is a naturally occurring amino acid derivative found mostly in skeletal muscle and other energy-demanding tissues like the brain. Creatine is converted into phosphocreatine by cells in our body and this creatine-phospocreatine system functions as a rapid-response energy reservoir. The body needs to replenish about 1-3 g of creatine per day to maintain normal creatine stores depending on muscle mass (clinical populations and athletes may need more (up to 30 g/day). Supplementation with creatine monohydrate is considered the most effective nutritional strategy for individuals wanting to maintain and increase strength by the International Society of Sports Nutrition, with over 680 peer-reviewed clinical trials.
I’m not an athlete. Why should I take creatine?
Muscle mass and strength decline faster starting around age 40—and by 80, the average person may lose approximately 30% of both. Supplementation with creatine is clinically proven to improve lean muscle mass and strength when combined with exercise. Elysium’s Creatine+ is an advanced creatine system to help you stay stronger as you age while targeting multiple pathways of longevity.
Why does Creatine+ contain HMB?
HMB is a metabolite of the essential amino acid leucine and has been studied for nearly 30 years. HMB reduces muscle damage due to exercise and speed recovery by reducing muscle protein breakdown and promoting muscle protein synthesis. Clinical studies have also shown a synergistic effect of HMB when combined with creatine (at 3 g HMB + 10 g creatine monohydrate daily dose) on lean body mass and an additive effect on muscle strength during resistance training. HMB alone (at 3 g daily dose) has also been shown to improve muscle function in older adults in the absence of exercise. These participants had insufficient baseline levels of vitamin D3 and were supplemented with 2,000 IUs of D3 in addition to HMB.
What is urolithin A and why is it important?
Urolithin A is a naturally occurring compound produced by your gut bacteria when you consume certain foods like pomegranates, walnuts, and berries. It’s important for cellular health as it stimulates mitophagy, a cellular cleanup process that clears out old mitochondria to help rejuvenate cellular energy and function. Clinical trials have shown that urolithin A supplementation improves muscle endurance. Creatine+ contains a highly researched pomegranate extract standardized to high levels of punicalagins—the precursor molecules that your gut microbes use to synthesize urolithin A.
When should I expect to see benefits?
While individual results may vary, studies show that 3-5 g per day of creatine monohydrate results in creatine saturation in muscle at ~30 days. By 12 weeks, participants in studies demonstrate improved training adaptation and increased exercise capacity, along with gains in strength and muscle mass with exercise.
How does Creatine+ taste?
Each pouch of Creatine+ contains two delicious flavors: raspberry and pomegranate lemonade. Try adding it to sparkling water or iced tea for an even more refreshing take.
How do I take Creatine+?
We recommend mixing one stick pack in 8-12 fl oz of water and consuming once daily. The mixture should be consumed within a few hours as creatine begins to convert to creatinine if stored in solution for a prolonged period of time. We recommend keeping the solution cold/refrigerated if you need to wait to consume it.
Can I take more than one dose of Creatine+ per day?
While we recommend one stick pack of Creatine+ per day, which contains 5 g of creatine monohydrate and 1.5 g HMB, short-term studies show no adverse effects of supplementation with up to 20 g/day of creatine monohydrate. In fact, emerging studies suggest that short term supplementation of creatine at high doses (~2-4x Creatine+) may help alleviate fading of cognitive performance during times of mental stress, like sleep deprivation. HMB has also been studied up to 6 g doses with no adverse effects.
How do subscriptions work?
Our prepaid subscription plans are our most cost-effective options. When you select a prepaid annual plan, the pricing offers a savings to customers who commit to a long-term subscription, $55/pouch for an annual (12-month) subscription. These prepaid subscriptions are considered final sale, so if you cancel in the middle of an annual plan, you will continue to receive the remaining pouches, and the cancellation will take effect at the end of your plan before renewal. Our monthly subscriptions are $60/month and can be canceled at any time prior to your next shipment. You can also place a single-purchase order by selecting “Individual Purchase” on the checkout page for $70. Please contact our Customer Experience Team at care@elysiumhealth.com if you need to talk about your plan.
Where do you ship?
Creatine+, Cofactor, Vision, Index, and the Senolytic Complex are currently only available to ship and bill to addresses located in the U.S. Mosaic, Basis, Signal, Matter, and Format are available in the United States and Canada. Sign up for our newsletter here to be notified of updates related to the international availability of our products.
When will I receive my product?
From the time an order ships, our free standard shipping delivers in 5-7 business days. For an additional $25 fee, expedited shipping arrives in 2-3 business days. Please allow 1-2 business days to process your order.
Creatine 101: The Science
What is creatine? Benefits, safety, and the science behind this powerful nutrient
Creatine is a naturally occurring compound that helps your cells produce energy.
Creatine and brain health: Can this energy nutrient support cognitive resilience?
Creatine has long been recognized as one of the most effective nutritional strategies for supporting muscle strength and performance.
What is urolithin A? The gut-derived compound behind pomegranate's longevity potential
Urolithin A (UA) is a naturally occurring compound produced when certain gut microbes transform polyphenols found in foods such as pomegranates.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to screen, diagnose, treat, cure, or prevent any disease or condition or assess risk of any disease or condition. Unless advised by your healthcare professional, biological age should not be used to determine or alter any age-related health or medical treatments based on your chronological age.